Last updated on March 27, 2021
Carsil coated tablets are a medicine containing the active substance silymarin, an agent derived from
milk thistle seeds. Silymarin activates the synthesis of proteins and phospholipids in damaged hepatic
cells, stabilises cell membranes, binds free radicals (antioxydative activity), thereby protecting hepatic
cells from harmful effects.
Indications: Carsil is used in the supportive treatment of liver damage.
Do not use Carsil:
– if you are allergic to silymarin or any of the other ingredients of this medicine.
– if the patient is a child under 12 years of age, as there is insufficient clinical experience with administering the medicine to children.
Ingredients: The active substance is 40.9–56.3 mg of milk thistle dry extract (Silybi mariani fructus extractum siccum), corresponding to 22.5 mg of silymarin in the form of silibinin. The other ingredients are: Tablet core: lactose monohydrate, wheat starch, povidone, microcrystalline cellulose, magnesium stearate, talc, mannitol (E421), crospovidone, polysorbate 80, sodium bicarbonate. Tablet coating: cellulose acetate phthalate, diethyl phthalate, sucrose, gum acacia, gelatin, talc, titanium dioxide (E171), macrogol 6000, glycerol, black iron oxide (E172), red iron oxide (E172), methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216).
What Carsil looks like and contents of the pack. Standard round coated tablets, brown, odourless. 10 coated tablets in a PVC/aluminium blister pack; 8 blisters packs (80 coated tablets) in a cardboard carton with the package leaflet.
How to take Carsil:
Carsil coated tablets are administered orally before a meal; the tablets are administered whole with a sufficient amount of liquid.
Adults and adolescents
In severe cases, the loading dose is 4 tablets 3 times per day; in milder cases and as maintenance treatment, 1–2 tablets 2–3 times per day. The treatment should last for at least 3 months.
Children under the age of 12:
There is insufficient data on the administration of this medicine to children, due to which it is not recommended to children under the age of 12.
Storage. Do not store at a temperature higher than 25 ºC / 77 °F. Store in the original package in order to protect from moisture. Keep this medicine out of the sight and reach of children. Do not use after the expiry date which is stated on the package. The expiry date refers to the last day of that month.
Possible side effects and warnings
Ask your doctor for advice before using Carsil coated tablets if you have a disease related to hormonal disorders (e.g. uterine, ovarian, mammary gland or prostate tumour). Carsil coated tablets are used in the supportive treatment of liver damage; thus, you must continue eating properly and avoid using alcohol during the treatment. Carsil coated tablets can weaken the efficiency of oestrogen replacement treatment, oral anticontraceptives and tamoxifen. Carsil can increase the activity of medicines, such as diazepam, alprazolam, ketoconazole, lovastatin and viblastine. Carsil contains wheat starch. This medicine contains only very low levels of gluten (from wheat starch) and is very unlikely to cause problems if you have coeliac disease. One tablet contains no more than 3,95 micrograms of gluten. If you have wheat allergy (different from coeliac disease) you should not take this medicine. Carsil contains lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Carsil contains sucrose as excipient. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine. Carsil contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E 216). These agents can cause allergic reactions (that can be late phase reactions).
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