Last updated on February 23, 2022
Acic 200 mg is an anti-herpes drug. Acic 200 mg contains the active substance acyclovir, which has a strong antiviral effect. Herpes is a disease, which is caused by the Herpes simplex virus (HSV) and the Varicella zoster virus (VZV). Penetration of herpes-infected cells by acyclovir stops the virus from replicating, while having no effect on healthy cells. Aciclovir can be used to: treat chickenpox and shingles; treat cold sores, genital herpes and other herpes simplex infections; stop these problems returning after you have had them; stop these problems in people whose immune system works less well, which means their bodies are less able to fight infections.
Uses and active ingredients
Acic tablets are indicated for the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes (excluding neonatal HSV and severe HSV infections in immunocompromised children).
One tablet contains 200 mg of acyclovir. Other excipients are copolyvidone, lactose monohydrate, magnesium stearate, microcristalline cellulose, sodium starch glycolate. The tablet can be divided into equal parts.
The original packaging contains 25 tablets.
Directions For Use / Dosage
Adults. It is very important that treatment with aciclovir be started as quickly as possible – as soon as the first symptoms of the disease (pruritus, itchiness, and the first blisters) appear. The medication is administered with regular 4, 6, or 12-hour intervals. The interval may be longer during nighttime.
Herpes simplex infections 200 mg of acyclovir (1 tablet of Acic 200 mg) 5 times daily every 4 hours.
Prophylaxis of severe and very often recurring Herpes simplex infections In immunologically healthy patients, single doses of 200 mg (1 tablet of Acic 200 respectively) are administered 4 times daily every 6 hours. This can be replaced with administering 400 mg of acyclovir (2 tablets of Acic 200 respectively) twice daily with 12-hour intervals. In individual cases, prophylaxis is also effective when 200 mg of acyclovir (1 tablet of Acic 200 respectively) is administered thrice daily every 8 hours or 200 mg of acyclovir (1 tablet of Acic 200 respectively) are administered twice daily every 12 hours. If the infection recurs despite a total daily dose of 800 mg, 200 mg of acyclovir (1 tablet of Acic 200 mg) must be administered 5 times daily every 4 hours for five days – the same dosage that is used for treating herpes simplex infections. Herpes zoster infections in immunocompetent patients are treated with 800 mg of acyclovir 5 times daily. In immunocompromised patients, single doses of 200 mg of acyclovir (1 tablet of Acic 200 mg respectively) are administered 4 times daily every 6 hours for prophylaxis. In patients with severe immunodeficiency, e.g. after undergoing organ transplantation, single doses of 400 mg of acyclovir (2 tablets of Acic 200 respectively) are administered 4 times daily every 6 hours. Development of resistance has been reported in immunocompromised patients. This must be taken into account when determining the dose. In Herpes simplex infections in patients with severe immunodeficiency, severe primary genital herpes, and herpes zoster infections (especially in immunocompromised patients), as well as with potential drug metabolism disorders, injectable acyclovir should be used instead.
Children Herpes simplex infections. Children over the age of 2 are given the adult dose; children under 2 are given half of the adult dose. The symptoms of infection with the Herpes zoster infection are typically milder in children than in adults. Nevertheless, 20 mg/kg, up to 800 mg 4 times daily for five days may be administered to children with a severe disease.
The tablets must be administered with a sufficient amount of fluid, preferably after meals.
Duration of treatment The duration of treatment for Herpes simplex infections is 5 days, but it may be extended depending on the condition of the patient. The duration of prophylactic treatment for Herpes simplex infections in patients who have a normal immune response depends on the severity of the infection and the frequency of recurrences. However, the course of treatment must not be longer than 6–12 months. The duration of prophylactic treatment for herpes simplex infections in severely immunodeficient patients depends on the degree of immunocompromise and the persistence of the risk of infection
Storage. Keep this medication out of the sight and reach of children. Do not store at a temperature above 25ºC. Do not use this medication after the expiration date which is marked on the box. The expiration date refers to the last day of that month..
Side-effects, precautions and interactions
Do not take Acic 200 mg: – if you are allergic (hypersensitive) to aciclovir, valaciclovir, or any of the ingredients of Acic 200. Special caution is advised: – if you have immunodeficiency; – if you have impaired kidney function or oliguria; – if you are elderly; – if your body is dehydrated.
Like all medications, this medication can cause side effects, although not everyone experiences them. Frequent (affect up to 1–10 in 100 people) – headaches, dizziness – nausea, vomiting, diarrhoea, abdominal pain – itching, skin rash (incl. sensitivity to light) – weakness, fever Occasional (affect up to 1–10 in 1,000 people) – urticaria, intensified hair loss (this is seen in several conditions and a causative link to treatment with acyclovir has not been established).
Full information leaflet can be downloaded HERE > Acic 200mg Tablets Patient Information Leaflet.
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